The concerned study reveals the experimental investigation of the biological activity of Kandelia rheedei (Family: Rhizophoraceae) used as a traditional antidiabetic and hypolipidemic agent. Research was aimed to study the effect of Kandelia rheedei in both normal and alloxan induced diabetic rats. The ethanolic root extract of Kandelia rheedei at the dose of 400, 600 and 800 mg /kg body weight was administered orally once a day to the groups for 30 days. The fasting blood glucose, cholesterol, HDL cholesterol and serum triglyceride content were estimated in both normal and alloxan induced diabetic rats. The fasting blood glucose, cholesterol and serum triglyceride content were found to be significantly reduced (p<0.05) in treated rats whereas the extract also showed the potent elevation in the level of serum HDL cholesterol. The study reveals that Kandelia rheedei has significant antidiabetic activity and a hypolipidemic activity in alloxan induced and normal fasting rats. The extract seems promising for the development of a phytomedicine for diabetes mellitus.
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